Review of human interferons and the potential of their use in the complex therapy of a new coronavirus infection COVID-19

Interferons (IFNs) were first discovered over 60 years ago in a classic experiment by Isaacs and Lindenman showing that type I IFNs have antiviral activity. are widely used the treatment of multiple sclerosis, viral hepatitis B C, some forms cancer. Preliminary clinical data support efficacy IFN against potential pandemic viruses such as Ebola SARS. Nevertheless, more effective specific drugs found their place diseases. As COVID-19 (SARS-CoV-2) is evolving, being re-discussed one main pathogenic drugs, initial trials shown promising results reducing severity duration COVID-19. Although SARS-CoV-2 inhibits production IFN-β prevents full innate immune response to this virus, it sensitive activity externally administered IFN. The review presents current on classification mechanisms action Possible options for optimal use fight discussed.